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About Fidia

Italian excellence around the world

Fidia Farmaceutici has continued its commitment to research and development for several decades since its foundation in 1946, with the aim to offer integrated, effective and safe products and services to healthcare professionals, patients, and global partners, with the best cost/benefit ratio.

The acquisition of the Spanish company Soluciones Bioregenerativas in 2018, enabled Fidia to consolidate its know-how and global presence in the field of regenerative medicine, specifically, in joint care, wound care, aesthetic medicine and uro-gynecology, applying platelet-rich plasma (PRP) technology and using adipose tissue, which is a major source of cells and other factors with regenerative potential.

REGENERATIVE MEDICINE – Since 1963, Fidia has pioneered the clinical application of hyaluronic acid and has paved the way to the concept of tissue regeneration, as well as a novel medical approach. Today, Regenerative Medicine, more specifically Autologous Biological Therapy, offers Fidia the possibility to develop a full line of products, namely a PRP concentration system, a bone marrow concentrate (BMC) and a functionally closed system to obtain stromal vascular fraction (SVF)-enriched fat micrografts, thereby allowing physicians to tailor the best treatment to the individual patient, in areas such as musculoskeletal disorders, advanced wound care and aesthetic medicine.

WHY PRP?

AN EFFECTIVE BIOACTIVE THERAPY

Platelet-Rich Plasma (PRP) is a biological product obtained from the patient own blood (autologous) which contains a platelet concentration above normal basal value. Platelets and plasma of PRP contain a wide amount of growth factors (GFs) and other biomolecules that activate and accelerate the processes of repair and regeneration of tissues where they are administered.

EFFECTS IN WOUNDS

PRP leads to the formation of healthy granulation tissue, accelerates epithelial differentiation, enhances the organization of dermal collagen fibers reducing scar formation, increases significantly the wound contraction and re-epithelialization leading to early complete closure.

PRP creates a biological internal environment for tissue homeostasis restoration by providing to the wounded area several signaling cytokines and GFs that will induce the migration and proliferation of MSCs and fibroblasts, promote the regeneration of epithelial and endothelial cells, increase anti-inflammatory factors, angiogenic factors and proteins related to extracellular matrix remodeling.

PRP-treated wounds showed faster and significant increase in tissue perfusion which helps the formation of granulation tissue and a better collagen architecture.

Accelerates significantly the re-epithelialization process and reduce the inflammation process. Growth factors and cytokines play also a crucial role in controlling oxidative damage.

PRP exert antimicrobial activity against Staphylococcus aureus and Escherichia coli.

APPLICATIONS

Wounds, Ulcers, Scars and fibrosis, Burns, Fat grafting adjuvant, Skin grafting adjuvant

BIBLIOGRAPHY

1. Andia et al. Regen Med. 2013; 8(645-658).
2. Anitua et al. J Control Release. 2012 ;157(29-38).
3. Griffeth et al. PLoS ONE. 2014; 9:e1084395.
4. Lacci et al. Yale J Bio Med. 2010; 83(1-9).
5. Yung et al. J Sport med Art Reh Tech. 2017; 7(27-36).
6. Mazzucco et al. Transfusion. 2004; 44(1013-10018).
7. Amable et al. Stem Cell Res Ther. 2013; 4(67).
8. McAleer et al. Adv. Skin Wound Care. 2006; 19(354–363).
9. Chicharro-Alcántara et al. J.Funct Biomat. 2018;9,10.
10. Magalon et al. BMJ Open Sport Exerc Med. 2016; 4;2(1):e000060.
11. Lee JW et al. Dermatol Surg 2011; 37(7): 931–938.
12. Tehranian A et al. Iran Red Crescent Med J. 2016;18(7):e34449.
13. Ozcelik U et al. Med Sci Monit. 2016;22:1903-9.
14. Cervelli V et al. Tissue Eng Part C Methods. 2009 Dec;15(4):625-34.
15. Schade VL et al. Foot Ankle Spec. 2008 Jun;1(3):155-9.

HIGH-TISSUE PRP:
A UNIQUE TECHNOLOGY

USER FRIENDLY

HIGH-TISSUE PRP 20 ARE EASY TO USE AND HAVE SIMPLE STEP-BY-STEP

TOTAL PROTECTION

CLOSED SYSTEM

Blood and plasma transfer through a swabable luer valve, designed to fill, hold and release controlled amounts of fluids on demand.

USER PROTECTION
to ensure user safety at any time during handling, the kit has:

  • Safety mechanism to minimize the risk of a needlestick injury
  • Flexible cannulas

Blood withdrawal can be done under very different conditions and in a room other than the application room. The High-tissue tube remains sterile until the moment of blood transfer. Less handling, less risk of contamination of the High-tissue tube. High-tissue PRP is a single-use medical device.

FOR ALL THERAPEUTIC NEEDS IN OUTPATIENTS OR IN THE OPERATING ROOM:

KIT AVAILABLE:

  • High-tissue PRP 20

 

2 TYPES OF PRP:

  • VERY PURE PRP
  • LEUCO-RICH PRP

2 INDIVIDUAL STERILE KITS IN THE SAME PACK, WITH ALL COMPONENTS FOR:

EXTRACTION KIT

  • Collection of anticoagulated blood

 

PRP KIT

  • PRP processing, selection and activation

CELL FRIENDLY

Devices made of anti-electrostatic medical grade polymer with a nano-polished and coated surface to prevent platelets adhesion, which increase platelet recovery.

Exclusive soft centrifugation technology that optimizes the platelets and cells separation and concentration, preserving their integrity and viability.

Laminar flow selection system that allows precise PRP selection directly from the tube to the application syringe without platelet activation.

PRODUCES A UNIQUE PRP

PRP 20ml

VIDEOS

Manufactured by: Fidia Italy

 

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